I nearly always use a Légère Signature (number 3 or 2.75) and live it. I highly doubt that I\'d return to cane reeds.
Some people in Mr Vincent\'s own thread felt that the synthetic reeds could be a bit slippery. I have had no trouble at all with my Bonade inverted ligature, after I gave the inside a very slight sanding with some fine emery cloth wrapped round my finger. Before that, it wouldn\'t stay put with any reed.
In the end, I suppose you just have to try a synthetic reed and see if you get along with it. To me, the convenience and consistency trump anything else.